Animal models for COVID-19

被引：0

作者：

César Muñoz-Fontela

William E. Dowling

Simon G. P. Funnell

Pierre-S. Gsell

A. Ximena Riveros-Balta

Randy A. Albrecht

Hanne Andersen

Ralph S. Baric

Miles W. Carroll

Marco Cavaleri

Chuan Qin

Ian Crozier

Kai Dallmeier

Leon de Waal

Emmie de Wit

Leen Delang

Erik Dohm

W. Paul Duprex

Darryl Falzarano

Courtney L. Finch

Matthew B. Frieman

Barney S. Graham

Lisa E. Gralinski

Kate Guilfoyle

Bart L. Haagmans

Geraldine A. Hamilton

Amy L. Hartman

Sander Herfst

Suzanne J. F. Kaptein

William B. Klimstra

Ivana Knezevic

Philip R. Krause

Jens H. Kuhn

Roger Le Grand

Mark G. Lewis

Wen-Chun Liu

Pauline Maisonnasse

Anita K. McElroy

Vincent Munster

Nadia Oreshkova

Angela L. Rasmussen

Joana Rocha-Pereira

Barry Rockx

Estefanía Rodríguez

Thomas F. Rogers

Francisco J. Salguero

Michael Schotsaert

Koert J. Stittelaar

Hendrik Jan Thibaut

Chien-Te Tseng

机构：

[1] Bernhard Nocht Institute for Tropical Medicine,German Center for Infection Research (DZIF)

[2] Partner site Hamburg-Lübeck-Borstel-Riems,Department of Microbiology, Global Health and Emerging Pathogens Institute

[3] Centre for Epidemic Preparedness Innovations (CEPI),Department of Epidemiology

[4] National Infection Service,KU Leuven Department of Microbiology, Immunology and Transplantation

[5] Public Health England,Laboratory of Virology, National Institute of Allergy and Infectious Diseases

[6] World Health Organization,Animal Resources Program

[7] Icahn School of Medicine at Mount Sinai,Department of Microbiology and Molecular Genetics, Center for Vaccine Research

[8] Bioqual Inc,VIDO

[9] University of North Carolina at Chapel Hill,Intervac

[10] European Medicines Agency,Integrated Research Facility at Fort Detrick

[11] Institute of Laboratory Animal Sciences,Department of Microbiology and Immunology

[12] Chinese Academy of Medical Sciences and Peking Union Medical College,Vaccine Research Center, National Institute of Allergy and Infectious Diseases

[13] Clinical Monitoring Research Program Directorate,Department of Viroscience

[14] Frederick National Laboratory for Cancer Research,Department of Immunology, Center for Vaccine Research

[15] Rega Institute,Center for Immunology of Viral, Auto

[16] Laboratory of Virology and Chemotherapy,immune, Hematological and Bacterial diseases (IMVA

[17] Viroclinics Xplore,HB/IDMIT), Inserm, CEA

[18] National Institutes of Health,Division of Pediatric Infectious Diseases, Center for Vaccine Research

[19] University of Alabama at Birmingham,Wageningen Bioveterinary Research (WBVR)

[20] University of Pittsburgh,Center for Infection and Immunity

[21] University of Saskatchewan,Division of Infectious Diseases

[22] National Institute of Allergy and Infectious Diseases,Department of Microbiology and Immunology

[23] National Institutes of Health,Centre de Recerca en Sanitat Animal (CReSA, IRTA

[24] University of Maryland School of Medicine,UAB)

[25] National Institutes of Health,Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine

[26] Erasmus University Medical Center,Department of Microbiology and Immunology

[27] Emulate Inc,College of Veterinary Medicine

[28] University of Pittsburgh,Departament de Sanitat i Anatomia Animals

[29] Center for Biologics Evaluation and Research,Department of Health Sciences

[30] FDA,Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center

[31] Université Paris-Saclay,undefined

[32] University of Pittsburgh School of Medicine,undefined

[33] Wageningen University and Research,undefined

[34] Columbia Mailman |School of Public Health,undefined

[35] University of California San Diego,undefined

[36] University of Texas Medical Branch,undefined

[37] Campus Universitat Autònoma de Barcelona,undefined

[38] Institute of Diagnostic Virology,undefined

[39] Friedrich-Loeffler-Institut,undefined

[40] The University of Hong Kong,undefined

[41] University of Iowa,undefined

[42] Kansas State University,undefined

[43] Tulane National Primate Research Center,undefined

[44] Facultat de Veterinària,undefined

[45] UAB,undefined

[46] Australian Centre for Disease Preparedness,undefined

[47] CSIRO,undefined

[48] Geelong,undefined

[49] University of York,undefined

[50] Harvard Medical School,undefined

来源：

Nature | 2020年 / 586卷

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学科分类号：

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19.

引用

页码：509 / 515

页数：6

共 50 条

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Munoz-Fontela, Cesar
Dowling, William E.
Funnell, Simon G. P.
Gsell, Pierre-S.
Riveros-Balta, A. Ximena
Albrecht, Randy A.
Andersen, Hanne
Baric, Ralph S.
Carroll, Miles W.
Cavaleri, Marco
Qin, Chuan
Crozier, Ian
Dallmeier, Kai
de Waal, Leon
de Wit, Emmie
Delang, Leen
Dohm, Erik
Duprex, W. Paul
Falzarano, Darryl
Finch, Courtney L.
Frieman, Matthew B.
Graham, Barney S.
Gralinski, Lisa E.
Guilfoyle, Kate
Haagmans, Bart L.
Hamilton, Geraldine A.
Hartman, Amy L.
Herfst, Sander
Kaptein, Suzanne J. F.
Klimstra, William B.
Knezevic, Ivana
Krause, Philip R.
Kuhn, Jens H.
Le Grand, Roger
Lewis, Mark G.
Liu, Wen-Chun
Maisonnasse, Pauline
McElroy, Anita K.
Munster, Vincent
Oreshkova, Nadia
Rasmussen, Angela L.
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Salguero, Francisco J.
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