Immune evasive mechanisms contributing to persistent Leishmania donovani infection

被引：0

作者：

Simona Stäger

Trupti Joshi

Rashmi Bankoti

机构：

[1] The Johns Hopkins University School of Medicine,Department of Pharmacology and Molecular Sciences

来源：

Immunologic Research | 2010年 / 47卷

关键词：

Chronic infection; Parasites; Immune evasion; IL-10; CD8; T-cell exhaustion;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The protozoan parasite Leishmania donovani, a causative agent of visceral leishmaniasis, has evolved several strategies to interfere with the immune system and establish persistent infections that are potentially lethal. In this article, we discuss two mechanisms of immune evasion adopted by the parasite: the induction of immune suppressive IL-10 responses and the generation of poor and functionally impaired CD8+ T-cell responses.

引用

页码：14 / 24

页数：10

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