A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria

被引：0

作者：

Fiona Macintyre

Yeka Adoke

Alfred B. Tiono

Tran Thanh Duong

Ghyslain Mombo-Ngoma

Marielle Bouyou-Akotet

Halidou Tinto

Quique Bassat

Saadou Issifou

Marc Adamy

Helen Demarest

Stephan Duparc

Didier Leroy

Bart E. Laurijssens

Sophie Biguenet

Afizi Kibuuka

Antoinette Kitoto Tshefu

Melnick Smith

Chanelle Foster

Illse Leipoldt

Peter G. Kremsner

Bui Quang Phuc

Alphonse Ouedraogo

Michael Ramharter

机构：

[1] Medicines for Malaria Venture,Infectious Diseases Research Collaboration

[2] Tororo Hospital,Universite des Sciences de la Sante Gabon, Département de Parasitology, Malaria Clinical and Operational Research Unit

[3] Centre National de Recherche et de Formation sur le Paludisme,Centre de Recherche du Centre Hospitalier de Mont Amba, Kinshasa School of Public Health

[4] National Institute of Malariology,Department of Medicine I, Division of Infectious Diseases

[5] Parasitology and Entomology,undefined

[6] Centre de Recherches Médicales de Lambaréné,undefined

[7] Institut für Tropenmedizin,undefined

[8] Universität Tübingen,undefined

[9] Melen Hospital,undefined

[10] Institut de Recherche en Sciences de la Santé – Unité de Recherche Clinique de Nanoro,undefined

[11] ISGlobal,undefined

[12] Barcelona Ctr. Int. Health Res. (CRESIB),undefined

[13] Hospital Clínic - Universitat de Barcelona,undefined

[14] Centro de Investigação em Saúde de Manhiça (CISM),undefined

[15] ICREA,undefined

[16] Pediatric Infectious Diseases Unit,undefined

[17] Pediatrics Department,undefined

[18] Hospital Sant Joan de Déu (University of Barcelona),undefined

[19] Universidad Europea de Madrid,undefined

[20] Centre de Recherche sur le Paludisme Associé à la Grossesse et l’Enfance,undefined

[21] Faculte Des Sciences De La Sante,undefined

[22] BEL Pharm Consulting,undefined

[23] University of Kinshasa,undefined

[24] QuintilesIMS,undefined

[25] Department: Biostatistics,undefined

[26] Medical University of Vienna,undefined

[27] Bernhard Nocht Hospital for Tropical Diseases,undefined

[28] Bernhard Nocht Institute for Tropical Medicine and University Medical Center Hamburg-Eppendorf,undefined

来源：

BMC Medicine | / 15卷

关键词：

Artefenomel; OZ439; Piperaquine; Single dose combination treatment; Pharmacokinetics; Dose–response; modelling and simulation; Phase II B; Uncomplicated ; malaria; Children;

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[1] A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria
Macintyre, Fiona
Adoke, Yeka
Tiono, Alfred B.
Tran Thanh Duong
Mombo-Ngoma, Ghyslain
Bouyou-Akotet, Marielle
Tinto, Halidou
Bassat, Quique
Issifou, Saadou
Adamy, Marc
Demarest, Helen
Duparc, Stephan
Leroy, Didier
Laurijssens, Bart E.
Biguenet, Sophie
Kibuuka, Afizi
Tshefu, Antoinette Kitoto
Smith, Melnick
Foster, Chanelle
Leipoldt, Illse
Kremsner, Peter G.
Bui Quang Phuc
Ouedraogo, Alphonse
Ramharter, Michael
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[3] A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria
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