Synthesis and Pharmacological Properties of the Azo-Conjugate of Erythropoietin β with Poly(Ethylene Glycol)

被引：0
|
作者：
S. V. Sheremet’ev
D. V. Lonshakov
E. M. Belosludtseva
O. V. Borisova
A. V. Sidorova
A. V. Kalinskii
机构：
[1] FORT LLC,
[2] I. I. Mechnikov Institute of Vaccines and Sera,undefined
来源：
Pharmaceutical Chemistry Journal | 2021年 / 55卷
关键词：
PEGylated proteins; azo coupling; erythropoietin β; Mircera; pharmacokinetics; bioequivalence;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A conjugate of erythropoietin β with 30 kDa linear methoxy poly(ethylene glycol) characterized by the presence of an azo spacer between the protein fragment and poly(ethylene glycol) was developed for import-substitution of Mircera drug in the Russian Federation. The erythropoietic activity of the synthesized conjugate was determined. Its pharmacokinetics in CBA mice were found to be comparable to those of Mircera. The bioequivalence of the proposed azo conjugate and Mircera was established based on the calculated drug pharmacokinetic parameters in mice.
引用
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页码：698 / 705
页数：7
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