Hydrolysis of 7,7-substituted derivatives of 3-tert-butyl-3,4-dihydro-2H- thiazolo-[3,2-a][1,3,5]triazin-6(7H)-one

被引：0
|
作者：
Ramsh S.M. [1 ]
Ivanenko A.G. [2 ]
Shpilevyi V.A. [1 ]
Medvedskiy N.L. [1 ]
Kushakova P.M. [1 ]
机构：
[1] St. Petersburg State Technical University
[2] Institute of Toxicology, Ministry of Health Russian Federation
来源：
Chemistry of Heterocyclic Compounds | 2005年 / 41卷 / 7期
关键词：
3,3′-di-tert-butyl-3′,4′-dihydro-2′H- spiro[(perhydro-1,3-oxazine)-5,7′-thiazolo[3,2-a][1,3,5]triazin] -6′-one; 3-tert-butyl-7,7-bis(hydroxymethyl)-3,4-dihydro-2H-thiazolo[3,2-a] [1,3,5]triazin-6(7H)-one; Hydrolysis;
D O I：
10.1007/s10593-005-0249-6
中图分类号：
学科分类号：
摘要：
Alkaline hydrolysis of 3-tert-butyl-7,7-bis(hydroxymethyl)-3,4-dihydro-2H- thiazolo[3,2-a][1,3,5]-triazin-6(7H)-one can occur in three directions: with cleavage of the tetrahydrotriazine ring, with cleavage of the thiazolidine ring, and also with opening of both rings. Depending on the process conditions, either the hydrolysis product corresponding to the first direction or the hydrolytic decomposition products corresponding to the second and third directions can be obtained in preparative quantities. Hydrolysis of 3,3′-di-tert-butyl-3′,4′-dihydro-2′ H-spiro[(perhydro-1, 3-oxazine)-5,7′-thiazolo[3,2-a][1,3,5]triazin]-6′-one in (NH 4)2CO3 solution occurs in two steps: in the first step, cleavage of the tetrahydrotriazine ring occurs; and in the second step, opening of the perhydrooxazine ring occurs. ©2005 Springer Science+Business Media, Inc.
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页码：921 / 928
页数：7
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