Synthesis and Biological Activity of N-[3-(4-Substituted Phenyl)-3-hydroxypropyl]valines and -Tryptophans, and 3-{[3-Hydroxy-3-(4-substituted phenyl)propyl]amino}-3-phenylpropanoic Acids

被引：0

作者：

A. G. Agababyan

G. A. Gevorgyan

A. P. Avakyan

A. E. Tumadzhyan

R. G. Paronikyan

G. A. Panosyan

机构：

[1] Organic and Pharmaceutical Chemistry Science and Technology Center,Molecular Structure Study Center

[2] National Academy of Sciences of the Republic of Armenia,undefined

[3] A. L. Mndzhoyan Institute of Fine Organic Chemistry,undefined

[4] National Academy of Sciences of the Republic of Armenia,undefined

来源：

Pharmaceutical Chemistry Journal | 2013年 / 47卷

关键词：

N-[β-(4-substituted benzoyl)ethyl]amino acids; synthesis; reduction with NaBH; N-[3-(4-substituted phenyl)-3-hydroxypropyl]amino acids; 3-{[3-hydroxy-3-(4-substituted phenyl)propyl]amino}-3-phenylpropanoic acids; anti-inflammatory and anticonvulsive activities;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Reduction of N-[β-(4-substituted benzoyl)ethyl]amino acids with sodium borohydride yielded arylaliphatic aminopropanols containing amino acid fragments – N-[3-(4-substituted phenyl)-3-hydroxypropyl]valines,-tryptophans, and 3-{[3-hydroxy-3-(4-substituted phenyl)propyl]amino}-3-phenylpropanoic acids. Studies of the biological activities of these compounds showed that some had anti-inflammatory and anticonvulsive activities.

引用

页码：361 / 365

页数：4

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