A genome-wide association study of metabolic traits in human urine

被引：0

作者：

Karsten Suhre

Henri Wallaschofski

Johannes Raffler

Nele Friedrich

Robin Haring

Kathrin Michael

Christina Wasner

Alexander Krebs

Florian Kronenberg

David Chang

Christa Meisinger

H-Erich Wichmann

Wolfgang Hoffmann

Henry Völzke

Uwe Völker

Alexander Teumer

Reiner Biffar

Thomas Kocher

Stephan B Felix

Thomas Illig

Heyo K Kroemer

Christian Gieger

Werner Römisch-Margl

Matthias Nauck

机构：

[1] Institute of Bioinformatics and Systems Biology,Division of Genetic Epidemiology, Department of Medical Genetics

[2] Helmholtz Zentrum München,Department of Prosthetic Dentistry

[3] German Research Center for Environmental Health,Department of Restorative Dentistry

[4] Faculty of Biology,Department of Cardiology

[5] Ludwig-Maximilians-Universität,Department of Pharmacology

[6] Institute of Clinical Chemistry and Laboratory Medicine,undefined

[7] University of Greifswald,undefined

[8] Molecular and Clinical Pharmacology,undefined

[9] Innsbruck Medical University,undefined

[10] Chenomx Inc.,undefined

[11] Institute of Epidemiology II,undefined

[12] Helmholtz Zentrum München,undefined

[13] German Research Center for Environmental Health,undefined

[14] Institute of Epidemiology I,undefined

[15] Helmholtz Zentrum München,undefined

[16] German Research Center for Environmental Health,undefined

[17] Institute of Medical Informatics,undefined

[18] Biometry and Epidemiology,undefined

[19] Chair of Epidemiology,undefined

[20] Ludwig-Maximilians-Universität,undefined

[21] Klinikum Grosshadern,undefined

[22] Institute for Community Medicine,undefined

[23] University of Greifswald,undefined

[24] Interfaculty Institute for Genetics and Functional Genomics,undefined

[25] University of Greifswald,undefined

[26] Gerodontology and Biomaterials,undefined

[27] Centre of Oral Health,undefined

[28] University of Greifswald,undefined

[29] Unit of Periodontology,undefined

[30] Periodontology and Endodontology,undefined

[31] Center of Oral Health,undefined

[32] University of Greifswald,undefined

[33] University of Greifswald,undefined

[34] Unit for Molecular Epidemiology,undefined

[35] Helmholtz Zentrum München,undefined

[36] German Research Center for Environmental Health,undefined

[37] Center of Pharmacology and Experimental Therapeutics,undefined

[38] University of Greifswald,undefined

[39] Institute of Genetic Epidemiology,undefined

[40] Helmholtz Zentrum München,undefined

[41] German Research Center for Environmental Health,undefined

[42] Present address: Department of Physiology and Biophysics,undefined

[43] Weill Cornell Medical College in Qatar,undefined

[44] P.O. Box 24144,undefined

[45] Education City–Qatar Foundation,undefined

[46] Doha,undefined

[47] Qatar.,undefined

来源：

Nature Genetics | 2011年 / 43卷

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摘要：

Karsten Suhre and colleagues report a genome-wide association study of metabolic traits in human urine, using NMR spectrometry to measure 59 metabolites in urine from participants. They identify five loci influencing urine metabolite levels and point to a missense variant in AGXT2 as the likely cause of hyper-β-aminoisobutyric aciduria, a common inborn error of metabolism.

引用

页码：565 / 569

页数：4

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