ANCA-associated vasculitis: from bench research to novel treatments

Antineutrophil cytoplasmic autoantibody-associated vasculitides such as Wegener granulomatosis and microscopic polyangiitis are an important cause of renal failure. Current treatment strategies based on cyclophosphamide have improved patient survival, but are associated with considerable morbidity. In this Review, Pallan and colleagues discuss the current treatment strategies and describe how the continually growing understanding of disease pathogenesis is enabling the development of novel targeted therapies.