CpG island hypermethylation of the DNA: Perspectives of a molecular biomarker for prostate cancer [CpG-insel-hypermethylierung der DNA: Perspektiven eines molekularen biomarkers für das prostatakarzinom]

被引：0

作者：

Bastian P.J. ^{[1
,6
]}

Ellinger J. ^{[2
]}

Von Rücker A. ^{[3
]}

Müller S.C. ^{[2
]}

Yegnasubramanian S. ^{[4
]}

Nelson W.G. ^{[4
,5
]}

Stief C.G. ^{[1
]}

机构：

[1] Urologische Klinik und Poliklinik, Klinikum der Universität München-Grosshadern

[2] Klinik und Poliklinik für Urologie, Rheinische Friedrich-Wilhelms-Universität, Bonn

[3] Institut für Pathologie, Rheinische Friedrich-Wilhelms-Universität, Bonn

[4] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD

[5] Department of Urology, James Buchanan Brady Urological Institute, John Hopkins University School of Medicine, Baltimore, MD

[6] Urologische Klinik und Poliklinik, Klinikum der Universität München-Grosshadern, Ludwig-Maximilians-Universität München, 81377 München

来源：

Der Urologe | 2008年 / 47卷 / 9期

关键词：

Biomarker; CpG island; GSTP1; Methylation; Prostate cancer;

D O I：

10.1007/s00120-008-1836-9

中图分类号：

学科分类号：

摘要：

The exact classification of clinically significant versus insignificant prostate cancer displays one of major problems in current urological practice. Using novel molecular biomarkers, we are trying to decrease overdiagnosis of insignificant cancer. CpG island hypermethylation as a common epigenetic event is a well-recognized phenomenon during carcinogenesis. We have shown that hypermethylation at several gene loci distinguishes between benign and malignant forms of prostatic disorders. Furthermore using tests in cancer tissue and serum samples, one can draw prognostic conclusions and predict biochemical failure following radical prostatectomy with curative intent. © 2008 Springer Medizin Verlag.

引用

页码：1205 / 1207

页数：2

共 2 条

[1] CpG island hypermethylation of the DNA.: Perspectives of a molecular biomarker for prostate cancer
Bastian, P. J.
Ellinger, J.
von Ruecker, A.
Mueller, S. C.
Yegnasubramanian, S.
Nelson, W. G.
Stief, C. G.
[J]. UROLOGE, 2008, 47 (09): : 1205 - 1207
[2] Die GSTP1-CpG-Insel-Hypermethylierung als molekularer Marker des ProstatakarzinomsGSTP1 CpG island hypermethylation as a molecular marker in the carcinogenesis of prostate cancer
P. J. Bastian
M. Nakayama
A. M. De Marzo
W. G. Nelson
[J]. Der Urologe, Ausgabe A, 2004, 43 : 573 - 579

← 1 →