Regulation of Neutrophil Function by Marine n-3 Fatty Acids—A Mini Review

While normal functioning neutrophils contribute in various, critical ways to the maintenance of a stable immune system, their hypo- or hyper-activation has been implicated in the onset or exacerbation of multiple inflammatory conditions often affecting the vulnerable, aging population. As such, many would benefit from interventions capable of targeting neutrophils in disease-specific ways without disrupting their primary role in maintaining immune function. After consumption, marine omega-3 fatty acids are rapidly incorporated into the phospholipid bilayer of neutrophils, changing the fatty acid composition and consequently modifying neutrophil function. In addition to eicosanoid synthesis, the mechanisms by which marine n-3 fatty acids and their metabolites alter neutrophil function involve blockage of transcription factors that subsequently reduce pro-inflammatory gene expression by neutrophils and through the disruption of lipid rafts. In the current mini-review, a brief explanation of marine n-3 fatty acid metabolism is provided and the subsequent impact on neutrophil function is discussed. In addition, current evidence of the effects of marine n-3 fatty acid supplementation on neutrophil function from clinical trials conducted in the past 15 years is summarized.