Recent Developments in Understanding the Role of Aqueous Humor Outflow in Normal and Primary Open Angle Glaucoma

Primary open-angle glaucoma (POAG) is the second leading cause of blindness in the world’s rapidly aging population. POAG is characterized by progressive degeneration of neural structures in the posterior segment, often associated with a concomitant elevation of intraocular pressure (IOP). Changes in IOP are believed to be caused by a disruption in the normal outflow of aqueous humor (AH). This article reviews recent research associated with normal and POAG AH outflow. Novel findings elucidating biochemical and pathological changes in the ocular tissues affected in POAG are presented. Stem cell research, identification of lymphatic markers, and increased use of mouse models give researchers exciting new tools to understand AH outflow, changes associated with POAG, and identify underlying causes of the disease. © 2015, Springer Science + Business Media New York.