Understanding the impact of immune-mediated selection on lung cancer evolution

被引：0
|
作者：
Rachel Rosenthal
Charles Swanton
Nicholas McGranahan
机构：
[1] The Francis Crick Institute,Cancer Evolution and Genome Instability Laboratory
[2] University College London Cancer Institute,Cancer Research UK Lung Cancer Centre of Excellence
[3] University College London Hospitals,Department of Medical Oncology
[4] University College London,Cancer Genome Evolution Research Group, University College London Cancer Institute
来源：
British Journal of Cancer | 2021年 / 124卷
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学科分类号：
摘要：
Understanding how a tumour evolves and avoids immune recognition is paramount to improving cancer immunotherapy and patient outcome. Here we examine our recent integration of multi-region genomic, transcriptomic, epigenomic, pathology, and clinical data, highlight the need for a systematic examination of immune escape mechanisms, and discuss implications for immunotherapy approaches.
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页码：1615 / 1617
页数：2
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