Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation

被引：0
|
作者：
Marnie E Gelbart
Erica Larschan
Shouyong Peng
Peter J Park
Mitzi I Kuroda
机构：
[1] Brigham & Women's Hospital,Division of Genetics, Department of Medicine
[2] Harvard Medical School,Department of Genetics
[3] Children's Hospital Informatics Program,undefined
[4] Children's Hospital,undefined
来源：
Nature Structural & Molecular Biology | 2009年 / 16卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Male Drosophila X chromosomes are highly transcribed to achieve dosage parity with females. This process is mediated by the MSL complex, though binding has been detected at only a subset of X chromosomal loci. MSL-dependent histone H4K16 acetylation is now found across the male X, suggesting widespread, but transient, MSL function.
引用
收藏
页码：825 / 832
页数：7
相关论文
共 50 条
  • [1] Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation
    Gelbart, Marnie E.
    Larschan, Erica
    Peng, Shouyong
    Park, Peter J.
    Kuroda, Mitzi I.
    [J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2009, 16 (08) : 825 - U47
  • [2] The Drosophila MSL complex acetylates histone h4 at lysine 16, a chromatin modification linked to dosage compensation
    Smith, ER
    Pannuti, A
    Gu, WG
    Steurnagel, A
    Cook, RG
    Allis, CD
    Lucchesi, JC
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (01) : 312 - 318
  • [3] The CLAMP protein links the MSL complex to the X chromosome during Drosophila dosage compensation
    Soruco, Marcela M. L.
    Chery, Jessica
    Bishop, Eric P.
    Siggers, Trevor
    Tolstorukov, Michael Y.
    Leydon, Alexander R.
    Sugden, Arthur U.
    Goebel, Karen
    Feng, Jessica
    Xia, Peng
    Vedenko, Anastasia
    Bulyk, Martha L.
    Park, Peter J.
    Larschan, Erica
    [J]. GENES & DEVELOPMENT, 2013, 27 (14) : 1551 - 1556
  • [4] Msl1-Mediated Dimerization of the Dosage Compensation Complex Is Essential for Male X-Chromosome Regulation in Drosophila
    Hallacli, Erinc
    Lipp, Michael
    Georgiev, Plamen
    Spielman, Clare
    Cusack, Stephen
    Akhtar, Asifa
    Kadlec, Jan
    [J]. MOLECULAR CELL, 2012, 48 (04) : 587 - 600
  • [5] Drosophila dosage compensation: a complex voyage to the X chromosome
    Gelbart, Marnie E.
    Kuroda, Mitzi I.
    [J]. DEVELOPMENT, 2009, 136 (09): : 1399 - 1410
  • [6] ACETYLATED HISTONE H4 ON THE MALE X-CHROMOSOME IS ASSOCIATED WITH DOSAGE COMPENSATION IN DROSOPHILA
    BONE, JR
    LAVENDER, J
    RICHMAN, R
    PALMER, MJ
    TURNER, BM
    KURODA, MI
    [J]. GENES & DEVELOPMENT, 1994, 8 (01) : 96 - 117
  • [7] Role of MSL2 domains in specific recruiting of the dosage compensation complex on the X chromosome in Drosophila melanogaster
    Tikhonova, E.
    Mogila, V.
    Maksimenko, O.
    Georgiev, P.
    [J]. FEBS OPEN BIO, 2018, 8 : 139 - 139
  • [8] Multiple classes of MSL binding sites target dosage compensation to the X chromosome of Drosophila
    Oh, H
    Bone, JR
    Kuroda, MI
    [J]. CURRENT BIOLOGY, 2004, 14 (06) : 481 - 487
  • [9] Dosage compensation in drosophila: Sequence-specific initiation and sequence-independent spreading of MSL complex to the active genes on the male X chromosome
    Gorchakov, Andrey A.
    Alekseyenko, Artyom A.
    Kharchenko, Peter V.
    Park, Peter J.
    Kuroda, Mitzi I.
    [J]. RUSSIAN JOURNAL OF GENETICS, 2010, 46 (10) : 1263 - 1266
  • [10] Dosage compensation in drosophila: Sequence-specific initiation and sequence-independent spreading of MSL complex to the active genes on the male X chromosome
    Andrey A. Gorchakov
    Artyom A. Alekseyenko
    Peter V. Kharchenko
    Peter J. Park
    Mitzi I. Kuroda
    [J]. Russian Journal of Genetics, 2010, 46 : 1263 - 1266
12345