Short Cell-Penetrating Peptides: A Model of Interactions with Gene Promoter Sites

被引：0
|
作者：
V. Kh. Khavinson
S. I. Tarnovskaya
N. S. Linkova
V. E. Pronyaeva
L. K. Shataeva
P. P. Yakutseni
机构：
[1] Russian Academy of Sciences,I. P. Pavlov Institute of Physiology
[2] St. Petersburg Institute of Bioregulation and Gerontology,undefined
[3] St. Petersburg State Polytechnical University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2013年 / 154卷
关键词：
cell penetrating peptides; molecular simulation; DNA-peptide interactions;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Analysis of the main parameters of molecular mechanics (number of hydrogen bonds, hydrophobic and electrostatic interactions, DNA-peptide complex minimization energy) provided the data to validate the previously proposed qualitative models of peptide–DNA interactions and to evaluate their quantitative characteristics. Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules.
引用
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页码：403 / 408
页数：5
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