Stem cell mobilization in patients with newly diagnosed multiple myeloma after lenalidomide induction therapy

被引：0

作者：

F Cavallo

S Bringhen

G Milone

D Ben-Yehuda

A Nagler

E Calabrese

N Cascavilla

V Montefusco

B Lupo

A M Liberati

C Crippa

F Rossini

R Passera

F Patriarca

A M Cafro

P Omedè

A M Carella

J Peccatori

L Catalano

T Caravita

P Musto

M T Petrucci

M Boccadoro

A Palumbo

机构：

[1] Myeloma Unit,Division of Hematology

[2] University of Torino,Division of Hematology

[3] AOU S Giovanni Battista,Hematology Division and Cord Blood Bank

[4] Ferrarotto Hospital,Department of Hematology

[5] Hadassah Medical Centre,Department of Stem Cell Transplant

[6] Chaim Sheba Medical Center,Division of Hematology

[7] Sapienza University of Rome,Department of Onco

[8] Unit of Hematology,Hematology

[9] Casa Sollievo della Sofferenza Hospital,Division of Hematology

[10] UO of Hematology and Allogeneic Bone Marrow Transplantation,Division of Hematology

[11] Istituto Nazionale per lo Studio e la Cura dei Tumori,Department of Onco

[12] Institute of Onco-Hematology,Hematology

[13] University of Perugia,undefined

[14] Santa Maria Hospital,undefined

[15] Spedali Civili Hospital,undefined

[16] Division of Hematology and TMO S Gerardo Hospital,undefined

[17] Radiochemistry Unit c/o SC Medicina Nucleare 2,undefined

[18] Azienda Ospedaliero-Universitaria San Giovanni Battista,undefined

[19] Clinic of Hematology,undefined

[20] Transplant Center and Cell Therapy ‘Carlo Melzi’,undefined

[21] AOU ‘S Maria della Misericordia’,undefined

[22] Haematology Departement,undefined

[23] Niguarda Hospital,undefined

[24] Hematology 1,undefined

[25] AOU S. Martino,undefined

[26] Hematology 1,undefined

[27] Istituto Scientifico Universitario San Raffaele,undefined

[28] University of Federico II,undefined

[29] S Eugenio Hospital,undefined

[30] IRCCS,undefined

[31] Centro di Riferimento Oncologico della Basilicata,undefined

来源：

Leukemia | 2011年 / 25卷

关键词：

myeloma; lenalidomide; mobilization; novel agent; transplantation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Lenalidomide has raised concerns regarding its potential impact on the ability to collect stem cells for autologous stem cell transplantation, especially after prolonged exposure. The use of cyclophosphamide plus granulocyte colony-stimulating factor (G-CSF) to mobilize peripheral blood stem cells may overcome this concern. In newly diagnosed multiple myeloma (MM) patients, we investigated the influence of lenalidomide on stem cell collection. In a prospective study, 346 patients received four cycles of lenalidomide–dexamethasone (Rd). Stem cells were mobilized with cyclophosphamide and G-CSF. Patients failing to collect a minimum of 4 × 106 CD34+/kg cells received a second mobilization course. After mobilization, a median yield of 8.7 × 106 CD34+/kg was obtained from patients receiving Rd induction. After first mobilization, inadequate yield was observed in 21% of patients, whereas only 9% of patients failed to collect the target yield after the second mobilization attempt. In conclusion, we confirm that a short induction with lenalidomide allowed sufficient stem cells collection to perform autologous transplantation in 91% of newly diagnosed patients.

引用

页码：1627 / 1631

页数：4

共 50 条

[1] Stem cell mobilization in patients with newly diagnosed multiple myeloma after lenalidomide induction therapy
Cavallo, F.
Bringhen, S.
Milone, G.
Ben-Yehuda, D.
Nagler, A.
Calabrese, E.
Cascavilla, N.
Montefusco, V.
Lupo, B.
Liberati, A. M.
Crippa, C.
Rossini, F.
Passera, R.
Patriarca, F.
Cafro, A. M.
Omede, P.
Carella, A. M.
Peccatori, J.
Catalano, L.
Caravita, T.
Musto, P.
Petrucci, M. T.
Boccadoro, M.
Palumbo, A.
[J]. LEUKEMIA, 2011, 25 (10) : 1627 - 1631
[2] Induction Therapy and Stem Cell Mobilization in Patients with Newly Diagnosed Multiple Myeloma
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[3] STEM CELL MOBILIZATION IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA FOLLOWING THERAPY WITH LENALIDOMIDE AND DEXAMETHASONE
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[6] Stem cell mobilization and autologous stem cell transplantation after induction with Bendamustine, Prednisone and Bortezomib (BPV) in newly diagnosed multiple myeloma patients
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