Ink4c is dispensable for tumor suppression in Myc-induced B-cell lymphomagenesis

被引：0
|
作者：
L M Nilsson
U B Keller
C Yang
J A Nilsson
J L Cleveland
M F Roussel
机构：
[1] St Jude Children's Research Hospital,Department of Biochemistry
[2] St Jude Children's Research Hospital,Department of Genetics and Tumor Cell Biology
[3] Umeå University,Department of Molecular Biology
来源：
Oncogene | 2007年 / 26卷
关键词：
p18; Arf; Myc; lymphomagenesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
p18Ink4c functions as a dedicated inhibitor of cyclin-D-dependent kinases. Loss of Ink4c predisposes mice to tumor development and, in a dose-dependent manner, complements the tumor-promoting effects of various oncogenes. We have now addressed whether Ink4c loss impacts B-cell tumor development in the Eμ-Myc transgenic mouse, a model of human Burkitt lymphoma. Loss of one or both alleles did not influence the onset of lymphoma in Eμ-Myc transgenics, and did not appreciably affect Myc's proliferative or apoptotic responses in precancerous B cells. Nevertheless, Ink4c loss modulated the effects of Myc-induced transformation by decreasing the frequency of Arf loss, an ordinarily common event in Eμ-Myc-induced lymphomas.
引用
收藏
页码：2833 / 2839
页数：6
相关论文
共 50 条
  • [1] Ink4c is dispensable for tumor suppression in Myc-induced B-cell lymphomagenesis
    Nilsson, L. M.
    Keller, U. B.
    Yang, C.
    Nilsson, J. A.
    CLeveland, J. L.
    Roussel, M. F.
    ONCOGENE, 2007, 26 (20) : 2833 - 2839
  • [2] Id2 is dispensable for Myc-induced lymphomagenesis
    Nilsson, JA
    Nilsson, LM
    Keller, U
    Yokota, Y
    Boyd, K
    Cleveland, JL
    CANCER RESEARCH, 2004, 64 (20) : 7296 - 7301
  • [3] Nfkb1 is dispensable for Myc-induced lymphomagenesis
    Keller, U
    Nilsson, JA
    Maclean, KH
    Old, JB
    Cleveland, JL
    ONCOGENE, 2005, 24 (41) : 6231 - 6240
  • [4] Nfkb1 is dispensable for Myc-induced lymphomagenesis
    Ulrich Keller
    Jonas A Nilsson
    Kirsteen H Maclean
    Jennifer B Old
    John L Cleveland
    Oncogene, 2005, 24 : 6231 - 6240
  • [5] Functional validation of genes implicated in lymphomagenesis -: An in vivo selection assay using a Myc-induced B-cell tumor
    Yu, DN
    Cozma, D
    Park, A
    Thomas-Tikhonenko, A
    TUMOR PROGRESSION AND THERAPEUTIC RESISTANCE, 2005, 1059 : 145 - 159
  • [6] p53-dependent senescence delays Eμ-myc-induced B-cell lymphomagenesis
    S M Post
    A Quintás-Cardama
    T Terzian
    C Smith
    C M Eischen
    G Lozano
    Oncogene, 2010, 29 : 1260 - 1269
  • [7] Transcriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis
    Farria, Aimee T.
    Plummer, Joshua B.
    Salinger, Andrew P.
    Shen, Jianjun
    Lin, Kevin
    Lu, Yue
    McBride, Kevin M.
    Koutelou, Evangelia
    Dent, Sharon Y. R.
    CANCER RESEARCH, 2020, 80 (24) : 5543 - 5553
  • [8] p53-dependent senescence delays Eμ-myc-induced B-cell lymphomagenesis
    Post, S. M.
    Quintas-Cardama, A.
    Terzian, T.
    Smith, C.
    Eischen, C. M.
    Lozano, G.
    ONCOGENE, 2010, 29 (09) : 1260 - 1269
  • [9] A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis
    J Odvody
    T Vincent
    M P Arrate
    B Grieb
    S Wang
    J Garriga
    G Lozano
    T Iwakuma
    D S Haines
    C M Eischen
    Oncogene, 2010, 29 : 3287 - 3296
  • [10] A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis
    Odvody, J.
    Vincent, T.
    Arrate, M. P.
    Grieb, B.
    Wang, S.
    Garriga, J.
    Lozano, G.
    Iwakuma, T.
    Haines, D. S.
    Eischen, C. M.
    ONCOGENE, 2010, 29 (22) : 3287 - 3296
12345