Differentiation of mouse embryonic stem cells into a defined neuronal lineage

被引：0
|
作者：
Miriam Bibel
Jens Richter
Katrin Schrenk
Kerry Lee Tucker
Volker Staiger
Martin Korte
Magdalena Goetz
Yves-Alain Barde
机构：
[1] Friedrich Miescher Institute,
[2] Max-Planck Institute of Neurobiology,undefined
[3] Novartis Pharma AG Nervous System Research,undefined
[4] University of Heidelberg,undefined
[5] GSF Institute of Stem Cell Research,undefined
[6] Biocenter,undefined
[7] University of Basel,undefined
来源：
Nature Neuroscience | 2004年 / 7卷
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摘要：
Although it has long been known that cultured embryonic stem cells can generate neurons, the lineage relationships with their immediate precursors remain unclear. We report here that selection of highly proliferative stem cells followed by treatment with retinoic acid generated essentially pure precursors that markers identified as Pax-6-positive radial glial cells. As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics.
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页码：1003 / 1009
页数：6
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