Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells

被引：0
|
作者：
J Gong
L Chen
D Chen
M Kashiwaba
Y Manome
T Tanaka
D Kufe
机构：
[1] Dana-Farber Cancer Institute,Division of Cancer Pharmacology
[2] Harvard Medical School,undefined
来源：
Gene Therapy | 1997年 / 4卷
关键词：
dendritic cells; adenovirus; transduction; antitumor immunity; DF3/MUC1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Transduction of dendritic cells (DC) can result in presentation of tumor-associated antigens and induction of immunity against undefined epitopes. The present studies demonstrate adenovirus (Ad)-mediated transduction of the β-galactosidase gene in mouse DC. Similar transductions have been obtained with the gene encoding the DF3/MUC1 tumor-associated antigen. We show that the Ad-transduced DC are functional in primary allogeneic mixed lymphocyte reactions. Mice immunized with Ad-transduced DC develop cytotoxic T lymphocytes that are specific for the β-galactosidase or DF3/MUC1 antigens. The results also demonstrate that Ad.MUC1-transduced DC induce a specific response which inhibits the growth of DF3/MUC1- positive tumors. These findings support the usefulness of Ad-transduced DC for in vivo immunization against tumor-associated antigens.
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页码：1023 / 1028
页数：5
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