Allosteric potentiation of glycine receptor chloride currents by glutamate

被引：0
|
作者：
Jun Liu
Dong Chuan Wu
Yu Tian Wang
机构：
[1] Vancouver Coastal Health Research Institute,Brain Research Centre and Department of Medicine
[2] University of British Columbia,undefined
[3] Translational Medicine Research Center and Center for Neuropsychiatry and Graduate Institute for Immunology,undefined
[4] China Medical University Hospital,undefined
来源：
Nature Neuroscience | 2010年 / 13卷
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摘要：
Glycine is a promiscuous neurotransmitter, as it acts primarily on the Cl-conducting, inhibitory glycine receptors (GlyRs), but it can also act as an allosteric modulator of excitatory NMDARs. Here, the authors found a reciprocal relation in glutamate and its analogs potentiating GlyR current in the rat spinal cord neurons.
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页码：1225 / 1232
页数：7
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