Screening and Clinical Implications for BRCA1 and BRCA2 Mutation Carriers

被引：0
|
作者：
Sharon E. Plon
机构：
来源：
Journal of Mammary Gland Biology and Neoplasia | 1998年 / 3卷
关键词：
BRCA1; BRCA2; BREAST CANCER; OVARIAN CANCER; CANCER SUSCEPTIBILITY; GENES; MUTATION DETECTION;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this article, we review the history oftesting for mutations in breast cancer susceptibilitygenes and discuss the current state of testing formutations in BRCA1 and BRCA2 in different clinicalsettings including at-risk individuals and cancerpatients. The risk of breast cancer, other associatedmalignancies and prognosis in carriers of thesemutations are reviewed. A final section includesdiscussion of current recommendations for surveillance andthe need for further research to identify environmentaland genetic factors which modify the risk of developingcancer in mutation carriers.
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页码：377 / 387
页数：10
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