Lipophilic Imidazolylpyridines with Antimicrobial Activity

被引：0

作者：

T. S. Vedekhina

M. Z. Dogonadze

T. I. Vinogradova

M. V. Chudinov

A. Yu. Lukin

机构：

[1] Federal Medical Biological Agency,Lopukhin Federal Research and Clinical Center of Physical

[2] St. Petersburg State Research Institute of Phthisiopulmonology,Chemical Medicine

[3] Ministry of Health of Russia,undefined

[4] Lomonosov Institute of Fine Chemical Technologies,undefined

[5] MIREA – Russian Technological University,undefined

来源：

Pharmaceutical Chemistry Journal | 2023年 / 57卷

关键词：

lipophilicity; imidazolylpyridines; zinc triflate; antimicrobial activity; antituberculosis activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The reaction of nicotinic and isonicotinic propargylamides with lipophilic aliphatic amines yielded a series of 3- or 4-(5-methyl-1H-imidazol-2-yl)pyridines containing a lipophilic substituent in the imidazole ring 1-position. The new compounds were characterized by physicochemical methods. The antituberculosis and antimicrobial activities against ESKAPE pathogens were studied. 3-[1-(1-n-Octadecyl)-5-methyl-1Himidazol-2-yl]pyridine (IIId) had antituberculosis activity (MIC 6.2 μg/mL) while 3-[1-(1-adamantylmethyl)-5-methyl-1H-imidazol-2-yl]pyridine (IIIa) exhibited activity against S. aureus (MIC 16 μg/mL).

引用

页码：816 / 821

页数：5

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