Composite paraganglioma-ganglioneuroma of the urinary bladder: A clinicopathologic, immunohistochemical, and ultrastructural study of a case and review of the literature

Urinary bladder paragangliomas are rare. An 81-yr-old woman was admitted because of whole-stream painless hematuria. Investigations revealed a pedunculated bladder tumor. Pathological examination showed a biphasic tumor, composite paraganglioma-ganglioneuroma. The two separate components were documented by both immunohistochemical and ultrastructural studies. A review of the English literature on urinary bladder paragangliomas showed that the present case is the first case with this unique feature documented in detail, and the patient is the oldest one being reported.