Mapping complex disease loci in whole-genome association studies

被引：0
|
作者：
Christopher S. Carlson
Michael A. Eberle
Leonid Kruglyak
Deborah A. Nickerson
机构：
[1] University of Washington,Department of Genome Sciences
[2] Howard Hughes Medical Institute,Division of Human Biology
[3] Fred Hutchinson Cancer Research Center,undefined
[4] Fred Hutchinson Cancer Research Center,undefined
来源：
Nature | 2004年 / 429卷
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摘要：
Identification of the genetic polymorphisms that contribute to susceptibility for common diseases such as type 2 diabetes and schizophrenia will aid in the development of diagnostics and therapeutics. Previous studies have focused on the technique of genetic linkage, but new technologies and experimental resources make whole-genome association studies more feasible. Association studies of this type have good prospects for dissecting the genetics of common disease, but they currently face a number of challenges, including problems with multiple testing and study design, definition of intermediate phenotypes and interaction between polymorphisms.
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页码：446 / 452
页数：6
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