Impaired neutrophil actin assembly causes persistent CD11b expression and reduced primary granule exocytosis in Type II diabetes

被引：0
|
作者：
A. Advani
S. Marshall
T. Thomas
机构：
[1] Department of Medicine,
[2] Medical School,undefined
[3] University of Newcastle Upon Tyne,undefined
[4] Framlington Place,undefined
[5] Newcastle Upon Tyne,undefined
来源：
Diabetologia | 2002年 / 45卷
关键词：
CD11b/CD18 Type II diabetes cardiovascular disease cytoskeleton neutrophil;
D O I：
暂无
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学科分类号：
摘要：
Aims/hypothesis. Neutrophil dysfunction has a role in the pathogenesis of complications in Type II (non-insulin-dependent) diabetes mellitus. Neutrophils adhere through expression of the β2integrin CD11b/CD18 which closely associates with the actin cytoskeleton. The aim of this study was to investigate the effect of actin polymerisation on CD11b expression and exocytosis of the primary granule marker CD69 in neutrophils from patients with Type II diabetes.
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页码：719 / 727
页数：8
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