Dissecting microRNA-mediated regulation of stemness, reprogramming, and pluripotency

被引：23

作者：

Lee Y.J. ^{[1
]}

Ramakrishna S. ^{[2
,3
]}

Chauhan H. ^{[4
]}

Park W.S. ^{[5
]}

Hong S.-H. ^{[6
,7
]}

Kim K.-S. ^{[2
,3
]}

机构：

[1] MizMedi Women's Hospital, iDream Research Center, Seoul

[2] Hanyang University, Department of Biomedical Science, Graduate School of Biomedical Science and Engineering, 222 Wangsimni-ro, Seongdong-gu, Seoul

[3] Hanyang University, College of Medicine, Seoul

[4] Uppsala University, Uppsala

[5] Kangwon National University, Department of Physiology, School of Medicine, Chuncheon

[6] Kangwon National University, Department of Internal Medicine, School of Medicine, 1 Kangwondaehak-gil, Chuncheon-si, Gangwon-do

[7] Kangwon National University, Stem Cell Institute, Chuncheon

来源：

Cell Regeneration | / 5卷 / 1期

基金：

新加坡国家研究基金会;

关键词：

Embryonic stem cells; MiRNAs; Pluripotency; Reprogramming; Self-renewal;

D O I：

10.1186/s13619-016-0028-0

中图分类号：

学科分类号：

摘要：

Increasing evidence indicates that microRNAs (miRNAs), endogenous short non-coding RNAs 19-24 nucleotides in length, play key regulatory roles in various biological events at the post-transcriptional level. Embryonic stem cells (ESCs) represent a valuable tool for disease modeling, drug discovery, developmental studies, and potential cell-based therapies in regenerative medicine due to their unlimited self-renewal and pluripotency. Therefore, remarkable progress has been made in recent decades toward understanding the expression and functions of specific miRNAs in the establishment and maintenance of pluripotency. Here, we summarize the recent knowledge regarding the regulatory roles of miRNAs in self-renewal of pluripotent ESCs and during cellular reprogramming, as well as the potential role of miRNAs in two distinct pluripotent states (naïve and primed). © 2016 Lee et al.

引用

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