Molecular mechanism of signaling by tumor necrosis factor

被引：0
|
作者：
Jikun Zha
Hongbing Shu
机构：
[1] Peking University,College of Life Sciences
[2] National Jewish Medical and Research Center,undefined
来源：
Science in China Series C: Life Sciences | 2002年 / 45卷
关键词：
tumor necrosis factor; signal transduction; JNK kinase; NF-κB; apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Tumor necrosis factor (TNF) is an important cytokine with multiple biological effects, including cell growth, differentiation, apoptosis, immune regulation and induction of inflammation. The effects of TNF are mediated by two receptors, TNF-R1 and TNF-R2. The major signal transduction pathways triggered by TNF include those that lead to apoptosis, activation of transcription factor NF-κ B and protein kinase JNK. This review will discuss the molecular mechanisms of these signaling pathways.
引用
收藏
页码：113 / 119
页数：6
相关论文
共 50 条
  • [1] Molecular mechanism of signaling by tumor necrosis factor
    Zha, JK
    Shu, HB
    SCIENCE IN CHINA SERIES C-LIFE SCIENCES, 2002, 45 (02): : 113 - 119
  • [2] Molecular mechanism of signaling by tumor necrosis factor
    查纪坤
    舒红兵
    Science in China(Series C:Life Sciences), 2002, (02) : 113 - 119
  • [3] Tumor necrosis factor signaling
    Wajant, H
    Pfizenmaier, K
    Scheurich, P
    CELL DEATH AND DIFFERENTIATION, 2003, 10 (01): : 45 - 65
  • [4] Tumor necrosis factor signaling
    H Wajant
    K Pfizenmaier
    P Scheurich
    Cell Death & Differentiation, 2003, 10 : 45 - 65
  • [5] Tumor necrosis factor signaling mechanisms
    Goeddel, DV
    Rothe, M
    Hsu, HL
    FASEB JOURNAL, 1996, 10 (06): : 1597 - 1597
  • [6] Tumor necrosis factor signaling mechanisms
    Goeddel, DV
    HARVEY LECTURES, VOL 92, 1996-1997, 1998, 92 : 41 - 54
  • [7] Studies of the mechanism of inhibition of insulin signaling by tumor necrosis factor-alpha
    Peraldi, P
    Spiegelman, BM
    JOURNAL OF ENDOCRINOLOGY, 1997, 155 (02) : 219 - 220
  • [8] The molecular perspective: Tumor necrosis factor
    Goodsell, DS
    ONCOLOGIST, 2006, 11 (01): : 83 - 84
  • [9] Tumor necrosis factor signaling in hepatocyte apoptosis
    Hatano, Etsuro
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2007, 22 : S43 - S44
  • [10] Tumor Necrosis Factor-a Signaling in Macrophages
    Parameswaran, Narayanan
    Patial, Sonika
    CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2010, 20 (02): : 87 - 103
12345