A bibliometric analysis of research on proteomics in Science Citation Index Expanded

A bibliometric analysis was conducted to evaluate the global scientific output of proteomics research in the Science Citation Index Expanded from 1995 to 2010. The document types, languages, journals, categories, countries, and institutions were analyzed to obtain publication patterns. Research focuses and trends were revealed by a word cluster method related to author keywords, title, abstract, and KeyWords Plus. Bradford’s Law and the correlation between keywords and institutions were identified to look deeper into the nature works. Proteomics and Journal of Proteome Research published the most articles in proteomics research. The researchers focused on the categories of biochemical research methods, and biochemistry and molecular biology. The USA and Harvard University were the most productive country and institution, respectively, while China was the fastest-growing country due to the support by Chinese government. The distribution of author keywords provided the important clues of hot issues. Results showed that mass spectrometry and two-dimensional gel electrophoresis had been the most frequently used research methods in the past 16 years; and cancer proteomics had a strong potential in the near future. Furthermore, biologists contributed significantly to proteomics research, and were more likely to co-operate with medical scientists.