Early detection of hepatocellular carcinoma via no end-repair enzymatic methylation sequencing of cell-free DNA and pre-trained neural network

被引：0

作者：

Zhenzhong Deng

Yongkun Ji

Bing Han

Zhongming Tan

Yuqi Ren

Jinghan Gao

Nan Chen

Cong Ma

Yichi Zhang

Yunhai Yao

Hong Lu

Heqing Huang

Midie Xu

Lei Chen

Leizhen Zheng

Jianchun Gu

Deyi Xiong

Jianxin Zhao

Jinyang Gu

Zutao Chen

Ke Wang

机构：

[1] Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Department of Oncology

[2] Suzhou BamRock Biotechnology Ltd.,BamRock Research Department

[3] Nanjing University,Division of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School

[4] Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Department of Transplantation

[5] Hepatobiliary Center,College of Intelligence and Computing

[6] the First Affiliated Hospital of Nanjing Medical University,Department of Software Engineering

[7] Tianjin University,Infectious Disease Department

[8] Tsinghua University,Department of Pathology

[9] National Clinical Research Center for Hematologic Diseases,Department of Oncology, Shanghai Medical College

[10] Jiangsu Institute of Hematology,Department of Pathology

[11] The First Affiliated Hospital of Soochow University,Department of Interventional Medicine

[12] Suzhou Known Biotechnology Ltd,Liver Transplantation Center

[13] the First Affiliated Hospital of Soochow University,undefined

[14] Fudan University Shanghai Cancer Center,undefined

[15] Fudan University,undefined

[16] Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,undefined

[17] the affiliated hospital of infectious diseases of Soochow University,undefined

[18] Union Hospital,undefined

[19] Tongji Medical College,undefined

[20] Huazhong University of Science and Technology,undefined

[21] Suzhou Key Laboratory of Pathogen Bioscience and Anti-Infective Medicine,undefined

来源：

Genome Medicine | / 15卷

关键词：

Hepatocellular carcinoma; Early detection; Cell-free DNA; Circulating tumor DNA; Whole-genome methylation sequencing; Enzymatic conversion; Read level; Neural network; No end-repair enzymatic methyl-seq;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 29 条

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Deng, Zhenzhong
Ji, Yongkun
Han, Bing
Tan, Zhongming
Ren, Yuqi
Gao, Jinghan
Chen, Nan
Ma, Cong
Zhang, Yichi
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Lu, Hong
Huang, Heqing
Xu, Midie
Chen, Lei
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Zhao, Jianxin
Gu, Jinyang
Chen, Zutao
Wang, Ke
[J]. GENOME MEDICINE, 2023, 15 (01)
[2] Hepatocellular carcinoma detection via targeted enzymatic methyl sequencing of plasma cell-free DNA
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Hailing Zheng
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Yue Xiao
Jin Zheng
Xingqiang Zhu
Huan Xu
Zhi He
Qian Zhang
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Min Jiang
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[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2024, 39 (02) : 231 - 244
[9] Plasma cell-free DNA integrative analysis for early detection of hepatocellular carcinoma.
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