DNA-binding and photocleavage studies of metallofluorescein–porphyrin complexes of zinc(II) and copper(II)

被引：0
|
作者：
Jiazheng Lu
Weijian Pan
Rongwei He
Shuqiang Jin
Xiangwen Liao
Bin Wu
Ping Zhao
Haiwei Guo
机构：
[1] Guangdong Pharmaceutical University,School of Pharmacy
[2] The Peoples’ Hospital of Shiling Huadu District,School of Medicine Chemistry and Chemical Engineering
[3] Guangdong Pharmaceutical University,undefined
来源：
Transition Metal Chemistry | 2012年 / 37卷
关键词：
Porphyrin; Circular Dichroism; Absorption Titration; Intrinsic Binding Constant; Open Circular Form;
D O I：
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学科分类号：
摘要：
The DNA-binding behaviors of the fluorescein–porphyrinatozinc(II) complex Zn(Fl-PPTPP) (Fl-PPTPP = 5-(4-fluoresceinpropyloxy)phenyl-10,15,20-triphenylporphyrin) and fluorescein–porphyrinatocopper(II) complex Cu(Fl-PPTPP) with calf thymus DNA (CT-DNA) were investigated by UV–Vis absorption titrations, fluorescence spectra, viscosity measurements, thermal denaturation and circular dichroism. The results suggest that both complexes interact with CT-DNA by intercalation. In addition, their photocleavage reactions with pBR322 supercoiled plasmid DNA were investigated. Both complexes exhibit significant DNA cleavage activity, and singlet oxygen may play an important role in these reactions.
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页码：497 / 503
页数：6
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