Hepatic Findings in Long-Term Clinical Trials of Ximelagatran

被引：0
|
作者：
William M. Lee
Dominique Larrey
Rolf Olsson
James H. Lewis
Marianne Keisu
Laurent Auclert
Sunita Sheth
机构：
[1] University of Texas Southwestern Medical Center at Dallas,Service Hépato
[2] Hôpital Saint Eloi and INSERM U632,Gastroentérologie, CHU Montpellier
[3] Sahlgrenska University Hospital,undefined
[4] Georgetown University Medical Center,undefined
[5] AstraZeneca R&D Mölndal,undefined
[6] AstraZeneca LP,undefined
来源：
Drug Safety | 2005年 / 28卷
关键词：
Total Bilirubin Level; Atrial Fibrillation Group; Oral Direct Thrombin Inhibitor; Hepatic Enzyme Level; Bilirubin Level Elevation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective: In clinical trials, the efficacy and safety of the oral direct thrombin inhibitor ximelagatran have been evaluated in the prevention or treatment of thromboembolic conditions known to have high morbidity and mortality. In these studies, raised aminotransferase levels were observed during long-term use (>35 days). The aim of this analysis is to review the data regarding these hepatic findings in the long-term trials of ximelagatran.
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页码：351 / 370
页数：19
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