Parameters of Hemodynamic Allostasis in Patients of Various Age Groups with Essential Arterial Hypertension

We determined the criteria for the diagnosis of hemodynamic allostasis and compared it with the index of allostatic load in patients of different age group with essential arterial hypertension without metabolic syndrome. The study included 87 subjects divided into 3 groups: patients with essential arterial hypertension at the age ⩽60 years (n=31; group 1), patients with essential arterial hypertension above 60 years (n=41; group 2), and healthy volunteers (n=15; age 25-69 years, group 3). The data of 24-h BP monitoring were processed by methods of linear and nonlinear rhythm analysis. Based on the analysis, parameters were identified that allow determining the state of allostatic regulation of the 24-h dynamics of BP, as well as parameters that determine the allostatic hemodynamic load on the cardiovascular system. The data obtained were compared with the index of allostatic load in patients of both groups. Regulation of the hemodynamics in patients with essential hypertension without metabolic syndrome in both age groups remained within the limits of hemodynamic allostasis forming the allostatic load on the body, which does not depend on patient’s age.