Gene expression profiling of primary breast cancer

被引：15

作者：

Rouzier R. ^{[1
]}

Wagner P. ^{[1
]}

Morandi P. ^{[1
]}

Pusztai L. ^{[1
]}

机构：

[1] Dept. of Breast Medical Oncology, Univ. Texas M.D. Anderson Cancer Ctr, Houston, TX 77030

来源：

Current Oncology Reports | 2005年 / 7卷 / 1期

关键词：

Breast Cancer; Tamoxifen; Gene Expression Profile; Gene Expression Data; Reverse Transcription Polymerase Chain Reaction;

D O I：

10.1007/s11912-005-0024-y

中图分类号：

学科分类号：

摘要：

Gene expression profiling is a method to measure the expression of a large number of genes in tissue specimens simultaneously. This analytical technique is actively explored as an emerging diagnostic tool for breast cancer. An important assumption behind this research is that the constellation of multiple genes will be more predictive of clinical outcome than any single gene alone. Gene expression signatures were shown to predict prognosis of breast cancer as well as response to particular chemotherapy regimens. The first multigene predictor of prognosis after tamoxifen therapy is already commercially available in the United States. This article reviews recent advances in the clinical application of this technique to breast cancer. Copyright © 2005 by Current Science Inc.

引用

页码：38 / 44

页数：6

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