Transcriptional interference by antisense RNA is required for circadian clock function

被引：0
|
作者：
Zhihong Xue
Qiaohong Ye
Simon R. Anson
Jichen Yang
Guanghua Xiao
David Kowbel
N. Louise Glass
Susan K. Crosthwaite
Yi Liu
机构：
[1] The University of Texas Southwestern Medical Center,Department of Physiology
[2] 5323 Harry Hines Boulevard,Department of Clinical Sciences
[3] Dallas,Department of Plant and Microbial Biology
[4] Texas 75390,undefined
[5] USA,undefined
[6] Faculty of Life Sciences,undefined
[7] University of Manchester,undefined
[8] Manchester M13 9PT,undefined
[9] UK,undefined
[10] The University of Texas Southwestern Medical Center,undefined
[11] 5323 Harry Hines Boulevard,undefined
[12] Dallas,undefined
[13] Texas 75390,undefined
[14] USA,undefined
[15] University of California,undefined
来源：
Nature | 2014年 / 514卷
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摘要：
The transcriptions of frq sense and antisense RNAs are mutually inhibitory and form a double negative feedback loop required for robust and sustained circadian rhythmicity: antisense transcription inhibits sense expression by causing chromatin modifications and premature transcription termination.
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页码：650 / 653
页数：3
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