Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

被引：0

作者：

Jari Lahti

Samuli Tuominen

Qiong Yang

Giulio Pergola

Shahzad Ahmad

Najaf Amin

Nicola J. Armstrong

Alexa Beiser

Katharina Bey

Joshua C. Bis

Eric Boerwinkle

Jan Bressler

Archie Campbell

Harry Campbell

Qiang Chen

Janie Corley

Simon R. Cox

Gail Davies

Philip L. De Jager

Eske M. Derks

Jessica D. Faul

Annette L. Fitzpatrick

Alison E. Fohner

Ian Ford

Myriam Fornage

Zachary Gerring

Hans J. Grabe

Francine Grodstein

Vilmundur Gudnason

Eleanor Simonsick

Elizabeth G. Holliday

Peter K. Joshi

Eero Kajantie

Jaakko Kaprio

Pauliina Karell

Luca Kleineidam

Maria J. Knol

Nicole A. Kochan

John B. Kwok

Markus Leber

Max Lam

Teresa Lee

Shuo Li

Anu Loukola

Tobias Luck

Riccardo E. Marioni

Karen A. Mather

Sarah Medland

Saira S. Mirza

Mike A. Nalls

机构：

[1] University of Helsinki,Department of Psychology and Logopedics

[2] University of Turku,Turku Institute of Advanced Studies

[3] Boston University,Department of Biostatistics

[4] Johns Hopkins Medical Campus,Lieber Institute for Brain Development

[5] University of Bari Aldo Moro,Department of Basic Medical Science, Neuroscience, and Sense Organs

[6] Erasmus MC University Medical Center,Department of Epidemiology

[7] Murdoch University,Department of Mathematics and Statistics

[8] Framingham Heart Study,Department of Psychiatry and Psychotherapy

[9] University of Bonn,Cardiovascular Health Research Unit, Department of Medicine

[10] German Center for Neurodegenerative Diseases,Human Genetics Center, School of Public Health

[11] University of Washington,Human Genome Sequencing Center

[12] University of Texas Health Science Center at Houston,Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine

[13] Baylor College of Medicine,Usher Institute

[14] University of Edinburgh,Centre for Global Health Research, Usher Institute

[15] University of Edinburgh,Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology

[16] University of Edinburgh,Center for Translational and Computational Neuroimmunology

[17] University of Edinburgh,Translational Neurogenomics Laboratory

[18] Columbia University Medical Center,Survey Research Center, Institute for Social Research

[19] QIMR Berghofer Medical Research Institute,Department of Family Medicine

[20] University of Michigan,Department of Epidemiology

[21] University of Washington,Department of Global Health

[22] University of Washington,Institute of Public Health Genetics

[23] University of Washington,Robertson Center for Biostatistics

[24] University of Washington,McGovern Medical School, Brown Foundation Institute of Molecular Medicine

[25] University of Glasgow,Department of Psychiatry and Psychotherapy

[26] University of Texas Health Science Center at Houston,Channing Laboratory

[27] University Medicine Greifswald,Faculty of Medicine

[28] German Center for Neurodegenerative Diseases,Translational Gerontology Branch, National Institute on Aging

[29] Brigham and Women’s Hospital,School of Medicine and Public Health

[30] Harvard School of Public Health,Institute of Social and Preventive Medicine

[31] Icelandic Heart Assocation,National Institute for Health and Welfare

[32] University of Iceland,Hospital for Children and Adolescents

[33] Intramural Research Program,PEDEGO Research Unit, MRC Oulu

[34] National Institutes of Health,Institute for Molecular Medicine Finland (FIMM)

[35] University of Newcastle,Department of Public Health

[36] University of Lausanne,Department for Neurodegenerative Diseases and Geriatric Psychiatry

[37] Helsinki and Oulu,Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine

[38] Helsinki University Hospital and University of Helsinki,Neuropsychiatric Institute

[39] Oulu University Hospital and University of Oulu,Brain and Mind Centre

[40] University of Helsinki,School of Medical Sciences

[41] University of Helsinki,Department of Psychiatry

[42] University of Bonn,Psychiatry Research

[43] University of New South Wales,Stanley Center for Psychiatric Research

[44] Prince of Wales Hospital,Helsinki Biobank

[45] The University of Sydney,Department of Economic and Social Sciences & Institute of Social Medicine, Rehabilitation Sciences and Healthcare Research

[46] University of New South Wales,Centre for Cognitive Ageing and Cognitive Epidemiology

[47] University of Cologne,Sunnybrook Health Sciences Centre

[48] Zucker Hillside Hospital,Department of Neurology, Sunnybrook Health Sciences Centre

[49] Broad Institute,Laboratory of Neurogenetics

[50] University of Helsinki Central Hospital,Center for Neuroimaging, Department of Radiology and Imaging Sciences

来源：

Molecular Psychiatry | 2022年 / 27卷

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D O I：

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中图分类号：

学科分类号：

摘要：

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.

引用

页码：4419 / 4431

页数：12

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