Sentinel lymph node in melanoma [Sentinel lymph node beim melanom]

被引：0
|
作者：
Meyer T. [1 ,3 ]
Möhrle M. [2 ]
Garbe C. [2 ]
Hohenberger W. [1 ]
机构：
[1] Klinik und Poliklinik der Universität Erlangen-Nürnberg, Erlangen
[2] Sektion Dermatologische Onkologie, Universitäts-Hautklinik Tübingen
[3] Chirurgische Klinik Mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen
来源：
Der Chirurg | 2004年 / 75卷 / 8期
关键词：
Diagnostics; Melanoma; Prognosis; Sentinel node biopsy;
D O I：
10.1007/s00104-004-0934-5
中图分类号：
学科分类号：
摘要：
The procedure of sentinel node biopsy (SNB) has emerged as an important advance especially with respect to staging of malignant melanoma. Elective (prophylactic) lymph node dissection that had been practiced in primary melanoma with a suspected increased risk of (clinically occult) lymphatic metastasis has been replaced by SNB. Patients with proven metastatic involvement of the sentinel node (12-25%) can be specifically selected for regional lymph node dissection. Metastatic involvement of the sentinel node (SN) is a significant independent prognostic factor. The value of detecting metastasis by highly sensitive diagnostic tools such as RT-PCR is just as uncertain as is the therapeutic benefit of operative or conservative therapies in sentinel node-positive patients with respect to improving prognosis and is currently under study. © Springer-Verlag 2004.
引用
收藏
页码：774 / 780
页数：6
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