Effect of Cytotoxic Compounds on Activity of Antioxidant Enzyme System in MCF-7 and H1299 Cells

被引：0
|
作者：
V. A. Mumyatova
A. A. Balakina
N. V. Filatova
V. D. Sen’
A. G. Korepin
A. A. Terentev
机构：
[1] Russian Academy of Sciences,Institute of Problems Chemical Physics
来源：
Bulletin of Experimental Biology and Medicine | 2016年 / 161卷
关键词：
platinum(IV) amino nitroxyl complexes; superoxide dismutase; catalase; antioxidant system; reactive oxygen species;
D O I：
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中图分类号：
学科分类号：
摘要：
We studied the function of the antioxidant system in tumor cell lines MCF-7 and H1299 that differ by the state of tumor suppressor gene p53. Exposure to different classes of cytotoxic compounds induced several types of antioxidant system responses that depend on the type of cell line. The effects of platinum(II) and platinum(IV) complexes on activity of antioxidant enzymes vary, which can be explained by differences in their accumulation and biotransformation in tumor cells. Triazole and oxazolidinone derivatives had little effect on activity of superoxide dismutase and catalase in H1299 cells, but increased superoxide dismutase activity in MCF-7 cells.
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页码：179 / 183
页数：4
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