Antifungal activity against Candida albicans of methyl 3,5-dinitrobenzoate loaded nanoemulsion

被引：0
|
作者：
Allana Brunna Sucupira Duarte
Yunierkis Perez-Castillo
Danielle da Nóbrega Alves
Ricardo Dias de Castro
Rafael Limongi de Souza
Damião Pergentino de Sousa
Elquio Eleamen Oliveira
机构：
[1] Federal University of Paraíba,Post Graduation Program in Natural and Synthetic Bioactive Products
[2] Universidad de Las Américas,Bio
[3] Federal University of Paraíba,Cheminformatics Research Group and Escuela de Ciencias Físicas y Matemáticas
[4] State University of Paraíba,Laboratory of Experimental Pharmacology and Cell Culture, Department of Clinical and Social Dentistry
[5] Federal University of Paraíba,Laboratory of Synthesis and Drug Delivery
来源：
Brazilian Journal of Microbiology | 2024年 / 55卷
关键词：
3,5-dinitrobenzoic acid; Antifungal activity; Molecular docking; Nanoemulsion;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The objective of this study was to evaluate the antifungal activity of free methyl 3,5 dinitrobenzoate (MDNB) and its nanoemulsion (MDNB-NE) against strains of Candida albicans. Additionally, a molecular modeling study was also carried out to propose the mechanism of action and toxicity of MDNB. These results demonstrated the MDNB-NE presented a droplet size of 181.16 ± 3.20 nm and polydispersity index of 0.30 ± 0.03. MDNB and MDNB-NE inhibited the growth of all strains with minimum inhibitory concentrations of 0.27–1.10 mM. The biological results corroborated the molecular model, which pointed to a multi-target antifungal mechanism of action for MDNB in C. albicans. The study could serve as a basis for further research involving compounds with nitro groups with antifungal.
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页码：25 / 39
页数：14
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