A Bayesian adaptive design for two-stage clinical trials with survival data

被引：0
|
作者：
Uttam Bandyopadhyay
Atanu Biswas
Rahul Bhattacharya
机构：
[1] University of Calcutta,Department of Statistics
[2] Indian Statistical Institute,Applied Statistics Unit
[3] West Bengal State University,Department of Statistics
来源：
Lifetime Data Analysis | 2009年 / 15卷
关键词：
Censoring; Clinical trials; Ethical design; Optimal design; Survival data; Two-stage designs;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A randomized two-stage adaptive Bayesian design is proposed and studied for allocation and comparison in a phase III clinical trial with survival time as treatment response. Several exact and limiting properties of the design and the follow-up inference are studied, both numerically and theoretically, and are compared with a single-stage randomized procedure. The applicability of the proposed methodology is illustrated by using some real data.
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收藏
页码：468 / 492
页数：24
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