Micronucleus and antitumor activities of two newly synthesized pyrimidine derivatives

被引：0
|
作者：
Nersesyan A.K. [1 ]
Muradyan R.E. [2 ]
Arsenyan F.G. [2 ]
Danagulyan G.G. [3 ]
机构：
[1] National Center of Oncology, Yerevan
[2] Institute of Fine Organic Chemistry, Yerevan
[3] Institute of Organic Chemistry, Yerevan
来源：
Cell and Tissue Biology | 2008年 / 2卷 / 1期
关键词：
Antitumor activity; Cyclophosphamide; Ehrlich ascitic carcinoma; Mice; Micronuclei; Pyrazolo[1,5a] pyrimidine iodides;
D O I：
10.1134/S1990519X08010148
中图分类号：
学科分类号：
摘要：
Micronucleus and antitumor activities of two newly synthesized iodides of pyrazolo[1,5a]pyrimidines were studied on mice. Both compounds were slightly toxic and had no antitumor activity in mice with Ehrlich ascites carcinoma; only one of them had low micronucleus activity. Both compounds substantially increase the micronucleus as well as the antitumor activities of cyclophosphamide. © MAIK Nauka 2008.
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收藏
页码：93 / 96
页数：3
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