A combinatorially convenient version of synthesis of 5-substituted oxazole-4-carboxylic acid ethyl esters

被引：0
|
作者：
V. M. Tormyshev
T. V. Mikhalina
O. Yu. Rogozhnikova
T. I. Troitskaya
D. V. Trukhin
机构：
[1] Russian Academy of Sciences,Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division
来源：
Russian Journal of Organic Chemistry | 2006年 / 42卷
关键词：
Sodium; Chloride; Ester; Ethyl; Benzene;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Reaction of ethyl isocyanoacetic acid with sodium hydride in anhydrous benzene, followed by treatment with carboxylic acid chlorides or N-(acyloxy)pyrrolidine-2,5-diones, gives 5-substituted oxazole-4-carboxylic acid esters. The procedure is applicable to derivatives of various carboxylic acids, including saturated aliphatic, α,β-unsaturated, alicyclic, aromatic, heterocyclic, and N-Boc-protected amino acids.
引用
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页码：1031 / 1035
页数：4
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