Synthesis of 1,3-Bis[3-X-2-(X-acetoxy)propyl]-6-methyl- 1,2,3,4-tetrahydropyrimidine-2,4-diones

被引：0

作者：

V. P. Krivonogov

G. A. Sivkova

Yu. I. Murinov

G. G. Kozlova

I. B. Abdrakhmanov'

L. V. Spirikhin

N. G. Afzaletdinova

R. A. Khisamutdinov

机构：

[1] Institute of Organic Chemistry,Russian Academy of Sciences

[2] Ufa Research Center,undefined

来源：

Russian Journal of Organic Chemistry | 2001年 / 37卷

关键词：

Oxidation; Methyl; Chloride; Organic Chemistry; Pyrimidine;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A procedure was developed for synthesizing nitrogen-and-sulfur-containing pyrimidine derivatives by reactions of 1,3-bis(3-chloro-2-hydroxypropyl)-6-methyluracil with 1-butanethiol and chloroacetyl chloride, followed by treatment of the resulting 1,3-bis[3-chloro-2-(chloroacetoxy)propyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione with 1-butanethiol, morpholine, and piperidine. Oxidation of the sulfur-containing products with NaIO4 gave the corresponding sulfoxides.

引用

页码：1786 / 1790

页数：4

共 50 条

[1] Synthesis of 1,3-bis[3-X-2-(X-acetoxy)propyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-diones
Krivonogov, VP
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Kozlova, GG
Abdrakhmanov, IB
Spirikhin, LV
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[J]. RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2001, 37 (12) : 1786 - 1790
[2] Synthesis of 5-Alkyl-1,3-bis[2-hydroxy-3-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)propyl]-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-diones
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