A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores

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作者
Moonil Kang
Ting Fang Alvin Ang
Sherral A. Devine
Richard Sherva
Shubhabrata Mukherjee
Emily H. Trittschuh
Laura E. Gibbons
Phoebe Scollard
Michael Lee
Seo-Eun Choi
Brandon Klinedinst
Connie Nakano
Logan C. Dumitrescu
Alaina Durant
Timothy J. Hohman
Michael L. Cuccaro
Andrew J. Saykin
Walter A. Kukull
David A. Bennett
Li-San Wang
Richard P. Mayeux
Jonathan L. Haines
Margaret A. Pericak-Vance
Gerard D. Schellenberg
Paul K. Crane
Rhoda Au
Kathryn L. Lunetta
Jesse B. Mez
Lindsay A. Farrer
机构
[1] Boston University Chobanian & Avedisian School of Medicine,Department of Medicine (Biomedical Genetics)
[2] Boston University Chobanian & Avedisian School of Medicine,Department of Anatomy and Neurobiology
[3] Boston University Chobanian & Avedisian School of Medicine,Framingham Heart Study
[4] Boston University Chobanian & Avedisian School of Medicine,Slone Epidemiology Center
[5] University of Washington School of Medicine,Department of Medicine
[6] Veterans Affairs Puget Sound Health Care System,Geriatric Research, Education, and Clinical Center
[7] University of Washington School of Medicine,Department of Psychiatry and Behavioral Sciences
[8] Vanderbilt University Medical Center,Vanderbilt Memory & Alzheimer’s Center
[9] Vanderbilt Genetics Institute,Indiana Alzheimer’s Disease Research Center
[10] Vanderbilt University Medical Center,Department of Radiology and Imaging Services
[11] John P. Hussman Institute for Human Genomics,Department of Medical and Molecular Genetics
[12] Miller School of Medicine,Department of Epidemiology
[13] Indiana University School of Medicine,Rush Alzheimer’s Disease Center
[14] Indiana University School of Medicine,Department of Pathology and Laboratory Medicine
[15] Indiana University School of Medicine,Department of Neurology
[16] University of Washington,Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences
[17] Rush University Medical Center,Boston University Alzheimer’s Disease Research Center
[18] University of Pennsylvania Perelman School of Medicine,Department of Epidemiology
[19] Columbia University School of Medicine,Department of Biostatistics
[20] Case Western Reserve University,Department of Neurology
[21] Boston University Chobanian & Avedisian School of Medicine,Department of Ophthalmology
[22] Boston University School of Public Health,undefined
[23] Boston University School of Public Health,undefined
[24] Boston University Chobanian & Avedisian School of Medicine,undefined
[25] Boston University Chobanian & Avedisian School of Medicine,undefined
来源
Molecular Neurodegeneration | / 18卷
关键词
Alzheimer’s disease; Genome-wide association study; Cognitive domains; Longitudinal measures; Pleiotropy; Pathway analysis;
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