The Actin Cytoskeleton in Myelinating Cells

被引：0
|
作者：
Tanya L. Brown
Wendy B. Macklin
机构：
[1] University of Colorado School of Medicine,Department of Cell and Developmental Biology
[2] University of Colorado School of Medicine,Cell Biology, Stem Cells, and Development Graduate Program
来源：
Neurochemical Research | 2020年 / 45卷
关键词：
Actin cytoskeleton; Myelin; Oligodendrocyte; Schwann cell;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Myelinating cells of both the peripheral and central nervous systems (CNSs) undergo dramatic cytoskeletal reorganization in order to differentiate and produce myelin. Myelinating oligodendrocytes in the CNS show a periodic actin pattern, demonstrating tight regulation of actin. Furthermore, recent data demonstrate that actin polymerization drives early cell differentiation and that actin depolymerization drives myelin wrapping. Dysregulation of the actin cytoskeleton in myelinating cells is seen in some disease states. This review highlights the cytoskeletal molecules that regulate differentiation of and myelination by cells of the PNS and CNS, informing our understanding of neural development, in particular myelination.
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页码：684 / 693
页数：9
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