Impact of high human genetic diversity in Africa on immunogenicity and efficacy of RTS,S/AS01 vaccine

被引：0
|
作者：
Stephen Tukwasibwe
Gerald Mboowa
Ivan Sserwadda
Joaniter I. Nankabirwa
Emmanuel Arinaitwe
Isaac Ssewanyana
Yoweri Taremwa
Gerald Tumusiime
Moses R. Kamya
Prasanna Jagannathan
Annettee Nakimuli
机构：
[1] Infectious Diseases Research Collaboration,Infectious Diseases Institute
[2] College of Health Sciences,School of Medicine
[3] Makerere University,School of Medicine
[4] Uganda Christian University,undefined
[5] College of Health Sciences,undefined
[6] Makerere University,undefined
[7] Stanford University,undefined
来源：
Immunogenetics | 2023年 / 75卷
关键词：
Africa; Genetic variation; Malaria; RTS,S/AS01 vaccine;
D O I：
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中图分类号：
学科分类号：
摘要：
In modern medicine, vaccination is one of the most effective public health strategies to prevent infectious diseases. Indisputably, vaccines have saved millions of lives by reducing the burden of many serious infections such as polio, tuberculosis, measles, pneumonia, and tetanus. Despite the recent recommendation by the World Health Organization (WHO) to roll out RTS,S/AS01, this malaria vaccine still faces major challenges of variability in its efficacy partly due to high genetic variation in humans and malaria parasites. Immune responses to malaria vary between individuals and populations. Human genetic variation in immune system genes is the probable cause for this heterogeneity. In this review, we will focus on human genetic factors that determine variable responses to vaccination and how variation in immune system genes affect the immunogenicity and efficacy of the RTS,S/AS01 vaccine.
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页码：207 / 214
页数：7
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