Synthesis and biological evaluation of some new spiro derivatives of barbituric acid

A series of spiro-barbiturates has been synthesized using an appropriate synthetic route and characterized by elemental analyses and spectral data. All the synthesized compounds were screened in vivo for their anticonvulsant activity and acute toxicity. All the synthesized compounds were administered at doses of 30, 100, 200, and 300 mg/kg body weight and the anticonvulsant activity was noted at 1 h time intervals after drug administration. All the synthesized compounds were evaluated for the phenobarbitone-induced hypnosis potentiation test. All the synthesized compounds tested showed sedative-hypnotic and anticonvulsant activity, but spiro compounds 2 and 3 were the most potent sedative hypnotic and anticonvulsant agents.