Comparison of isotopic dilution methods for determination of theophylline in the plasma and saliva of infants and children

被引：0
|
作者：
M. Culea
N. Palibroda
P. Chereches-Panta
M. Nanulescu
机构：
[1] Institute of Isotopic and Molecular Technology,
[2] Pediatric Clinic III,undefined
来源：
Chromatographia | 2001年 / 53卷
关键词：
Gas chromatography-mass spectrometry; Isotopic dilution; Theophylline; Plasma and saliva of infants;
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学科分类号：
摘要：
Isotope-dilution mass spectrometry (IDMS) using the direct inlet probe and an isotope dilution gas chromatographic-mass spectrometric (GC-IDMS) technique are presented for determination of theophylline in paired specimens of plasma and saliva from infants and children treated with theophylline for idiopathic apnea of prematurity, or for asthma.15N-theophylline was used as internal standard. A non-invasive means of individualization of the dosage was achieved by analysis of levels of the drug in saliva secreted in response to stimulation with citric acid.
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页码：S387 / S389
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