Selenium and hydrogen selenide: essential micronutrient and the fourth gasotransmitter?

被引：0
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作者：
Mathun Kuganesan
Kavitej Samra
Eloise Evans
Mervyn Singer
Alex Dyson
机构：
[1] University College London,Bloomsbury Institute of Intensive Care Medicine, Division of Medicine
来源：
Intensive Care Medicine Experimental | / 7卷
关键词：
Selenium; Selenoprotein; Hydrogen sulfide; Metabolism; Redox; Oxidative stress; Oxidative phosphorylation; Cytochrome C oxidase; Mitochondria;
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摘要：
Selenium (Se) is an essential micronutrient required by organisms of diverse lineage. Dietary Se is converted to hydrogen selenide either enzymatically or by endogenous antioxidant proteins. This convergent biochemical step crucially underlies the subsequent biological activity of Se and argues for inclusion of hydrogen selenide as the fourth endogenous gasotransmitter alongside nitric oxide, carbon monoxide and hydrogen sulfide.
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