GABAergic inhibition in the rat pontine nuclei is exclusively extrinsic: evidence from an in situ hybridization study for GAD67 mRNA

被引：0

作者：

M. Möck

Cornelius Schwarz

Petra Wahle

Peter Thier

机构：

[1] Sektion für Visuelle Sensomotorik,

[2] Neurologische Universitätsklinik Tübingen,undefined

[3] Hoppe-Seyler-Strasse 3,undefined

[4] D-72076 Tübingen,undefined

[5] Germany e-mail: martin moeck@uni-tuebingen.de Tel.: +49-7071-2987643,undefined

[6] Fax: +49-7071-295724,undefined

[7] Lehrstuhl für Allgemeine Zoologie und Neurobiologie,undefined

[8] Ruhr-Universität,undefined

[9] Gebäude ND,undefined

[10] D-44780 Bochum,undefined

[11] Germany,undefined

来源：

Experimental Brain Research | 1999年 / 124卷

关键词：

Key words Cerebellum; Glutamic acid decarboxylase; GABA; Inhibition; Precerebellar nuclei;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

As clearly indicated by our electrophysiological work, GABAergic inhibition plays a powerful role in the pontine nuclei (PN), the major link between cerebral cortex and the cerebellum. Using the technique of in situ hybridization for the mRNA encoding for the γ-aminobutyric acid (GABA)-synthesizing isoenzyme glutamic acid decarboxylase67 (GAD67), we demonstrate here the total absence of potentially GABAergic neurons from the rat PN. This negative finding supports the notion that GABAergic inhibition in the PN of rats, unlike that of higher mammals, is exclusively based on extrapontine GABAergic afferents.

引用

页码：529 / 532

页数：3

共 10 条

[1] GABAergic inhibition in the rat pontine nuclei is exclusively extrinsic:: evidence from an in situ hybridization study for GAD67 mRNA
Möck, M
Schwarz, C
Wahle, P
Thier, P
EXPERIMENTAL BRAIN RESEARCH, 1999, 124 (04) : 529 - 532
[2] ALTERATIONS OF GABAERGIC NEURONS IN THE BASAL GANGLIA OF PATIENTS WITH SUPRANUCLEAR PALSY - AN IN-SITU HYBRIDIZATION STUDY OF GAD67 MESSENGER-RNA
LEVY, R
RUBERG, M
HERRERO, MT
VILLARES, J
JAVOYAGID, F
AGID, Y
HIRSCH, EC
NEUROLOGY, 1995, 45 (04) : A255 - A255
[3] Localization of cells preferentially expressing GAD67 with negligible GAD65 transcripts in the rat hippocampus.: A double in situ hybridization study
Stone, DJ
Walsh, J
Benes, FM
MOLECULAR BRAIN RESEARCH, 1999, 71 (02): : 201 - 209
[4] Changes in GAD67 mRNA expression evidenced by in situ hybridization in the brain of R6/2 transgenic mice
Gourfinkel-An, I
Parain, K
Hartmann, A
Mangiarini, L
Brice, A
Bates, G
Hirsch, EC
JOURNAL OF NEUROCHEMISTRY, 2003, 86 (06) : 1369 - 1378
[5] Effects of intralaminar thalamic nuclei lesion on glutamic acid decarboxylase (GAD65 and GAD67) and cytochrome oxidase subunit I mRNA expression in the basal ganglia of the rat
Bacci, JJ
Kerkerian-Le Goff, L
Salin, P
EUROPEAN JOURNAL OF NEUROSCIENCE, 2002, 15 (12) : 1918 - 1928
[6] ALTERATIONS OF GABAERGIC NEURONS IN THE BASAL GANGLIA OF PATIENTS WITH PROGRESSIVE SUPRANUCLEAR PALSY - AN IN-SITU HYBRIDIZATION STUDY OF GAD(67) MESSENGER-RNA
LEVY, R
RUBERG, M
HERRERO, MT
VILLARES, J
JAVOYAGID, F
AGID, Y
HIRSCH, EC
NEUROLOGY, 1995, 45 (01) : 127 - 134
[7] Decreased GAD65 mRNA Levels in Select Subpopulations of Neurons in the Cerebellar Dentate Nuclei in Autism: An In Situ Hybridization Study
Yip, Jane
Soghomonian, Jean Jacques
Blatt, Gene J.
AUTISM RESEARCH, 2009, 2 (01) : 50 - 59
[8] Evidence for a GABAergic projection from the central nucleus of the amygdala to the brainstem of the macaque monkey:: a combined retrograde tracing and in situ hybridization study
Jongen-Rêlo, AL
Amaral, DG
EUROPEAN JOURNAL OF NEUROSCIENCE, 1998, 10 (09) : 2924 - 2933
[9] EFFECTS OF NIGROSTRIATAL DENERVATION AND L-DOPA THERAPY ON THE GABAERGIC NEURONS OF THE STRIATUM IN MPTP-TREATED MONKEYS AND PARKINSONS-DISEASE - AN IN-SITU HYBRIDIZATION STUDY OF GAD(67) MESSENGER-RNA
LEVY, R
HERRERO, MT
RUBERG, M
VILLARES, J
FAUCHEUX, B
GURIDI, J
GUILLEN, J
LUQUIN, MR
JAVOYAGID, F
OBESO, JA
AGID, Y
HIRSCH, EC
EUROPEAN JOURNAL OF NEUROSCIENCE, 1995, 7 (06) : 1199 - 1209
[10] Blockade of A2A receptors plus L-DOPA after nigrostriatal lesion results in GAD67 mRNA changes different from L-DOPA alone in the rat globus pallidus and substantia nigra reticulata
Carta, AR
Tabrizi, MA
Baraldi, PG
Pinna, A
Pala, P
Morelli, M
EXPERIMENTAL NEUROLOGY, 2003, 184 (02) : 679 - 687

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