G-Csf receptor-mediated up-regulation of c-fos but not c-raf mRNA expression in myeloid cells

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作者
Rajendra V. Deshpande
Malcolm A.S. Moore
机构
[1] Memorial Sloan-Kettering Cancer Center,James Ewing Laboratory of Developmental Hematopoiesis, Program of Cell Biology and Genetics
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growth factor; receptor; signal transduction; myeloid;
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摘要
Granulocyte colony stimulating factor (G-CSF) regulates survival, proliferation, and differentiation of myeloid precursor cells. One of the signaling mechanisms for the G-CSF receptor (G-CSF-R) involves the activation of Ras/MAP kinase (MEK) pathway. Since Raf is an important, common link between Ras and MEK in the Ras-Raf-MEK cascade, we studied the expression of c-raf mRNA in G-CSF-treated myeloid precursor cell lines - NFS-60 and HL-60. G-CSF did not alter c-raf mRNA expression in these cells up to 24 h, but induced a transient up-regulation of c-fos mRNA expression between 15-60 min post-treatment. Our results show that G-CSF triggers a de novo induction of c-fos but not c-raf mRNA, and suggests that G-CSF-R-mediated activation of Ras/MEK pathway may involve post-transcriptional mechanisms of Raf regulation.
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页码:47 / 50
页数:3
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