The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)

被引：0

作者：

Maarten C Kraan

Dhavalkumar D Patel

Jasper J Haringman

Malcolm D Smith

Helen Weedon

Michael J Ahern

Ferdinand C Breedveld

Paul P Tak

机构：

[1] Academic Medical Center,Division of Clinical Immunology and Rheumatology, Department of Medicine

[2] Duke University Medical Center,Division of Rheumatology, Allergy and Clinical Immunology, Department of Medicine

[3] Repatriation General Hospital,Department of Rheumatology

[4] Leiden University Medical Center,undefined

来源：

Arthritis Research & Therapy | / 3卷

关键词：

arthritis; chemokines; CXCL8; patients; synovium;

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暂无

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摘要：

Paired synovial tissue samples were obtained from both clinically uninvolved (CU) and clinically involved (CI) knee joints of eight rheumatoid arthritis (RA) patients. In addition, biopsies were taken from five control subjects. We observed the expression of the chemokines CXCL8, CXCL9, CXCL10, CCL2 and CCL4 in CI and CU joints of RA patients. In particular, CXCL8 protein levels were specifically increased in CI joints compared with CU joints, which was confirmed by immunohistochemistry and in situ hybridization.

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